Growth restricted placentas show severely reduced volume of villous components with perivascular myofibroblasts
نویسندگان
چکیده
منابع مشابه
Reduced placental volume and flow in severe growth restricted fetuses
OBJECTIVES To evaluate placental volume and vascular indices in pregnancies with severe fetal growth restriction and determine their correlations to normal reference ranges and Doppler velocimetry results of uterine and umbilical arteries. METHODS Twenty-seven fetuses with estimated weights below the 3rd percentile for gestational age were evaluated. Placental volume and vascular indices, inc...
متن کاملIncreased Autophagy in Placentas of Intrauterine Growth-Restricted Pregnancies
BACKGROUND Unexplained intrauterine growth restriction (IUGR) may be a consequence of placental insufficiency; however, its etiology is not fully understood. We surmised that defective placentation in IUGR dysregulates cellular bioenergic homeostasis, leading to increased autophagy in the villous trophoblast. The aims of this work were (1) to compare the differences in autophagy, p53 expression...
متن کاملReduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion.
Low birth weight as the result of placental insufficiency increases the risk of hypertension in young adults; however, the vascular mechanisms involved are unclear. We tested the hypothesis that intrauterine fetal growth restriction caused by placental insufficiency results in low-birth-weight offspring with impaired endothelium-dependent vascular relaxation, enhanced vasoconstriction, and hype...
متن کاملNew Cascaded Multilevel Inverter With Reduced Power Electronic Components
In this paper, a new structure for cascade multilevel inverter is presented which consists of a series connection of several sub-multilevel units. Each sub-multilevel unit comprises of eight unidirectional switches, two bidirectional switches, and six DC voltage sources. For the proposed cascade topology, two algorithms are presented to produce all possible levels at the output voltage waveform...
متن کامل[A case of dwarfism with severely reduced activity of growth hormone-binding protein].
We presented a 16-year-old boy with severe growth retardation and markedly decreased levels of growth hormone-binding protein (GHBP) in plasma, which was shown to correspond to the extracellular composition of hepatic GH receptor and suggested to reflect tissue concentration of the receptor. His height was 92.5 cm (-13.5 SD), the weight 9.6kg (-5.8 SD) and Tanner stage was I. His bone age was 3...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Placenta
سال: 2021
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2021.04.006